Fig. 2. Brain areas with significant positive correlations between regional cerebral glucose metabolism and executive function in amnestic mild cognitive impairment (aMCI) with low Aβ burden. Statistical parametric maps showing positive correlations between Alzheimer's Disease Neuroimaging Initiative executive function composite scores and regional cerebral glucose metabolism using a multiple regression model with age, sex, education, and apolipoprotein E (APOE) genotype as covariates in aMCI with low Aβ burden. Significant regions have p<0.001 (uncorrected for multiple comparisons) with an extent threshold of greater than 50 contiguous voxels. The yellow-red color bar represents t-score.