Table 3. Multiple Linear Regression of ACC, PCC, and PreCu Regions of Interest at Baseline on 1-Year Follow-Up CDR-SOB^*.

Group	Variable	B	SE (B)	β	p value
aMCI Aβ−†	Age	0.011	0.013	0.078	0.385
	Education	−0.016	0.040	−0.032	0.695
	Sex	0.038	0.198	0.016	0.849
	APOE4	−0.176	0.175	−0.081	0.315
	ACC	−0.056	0.019	−0.260	0.003
aMCI Aβ+‡	Age	0.019	0.014	0.089	0.189
	Education	0.005	0.032	0.010	0.871
	Gender	0.343	0.196	0.114	0.081
	APOE4	0.252	0.142	0.115	0.077
	PCC	−0.044	0.015	−0.190	0.003

ACC, anterior cingulate cortex; PCC, posterior cingulate cortex; PreCu, precuneus; CDR-SOB, Clinical Dementia Rating sum of boxes; aMCI Aβ−, amnestic mild cognitive impairment with low Aβ burden; aMCI Aβ+, amnestic mild cognitive impairment with high Aβ burden; APOE, apolipoprotein E; B, regression coefficient; SE (B), standard error of B; β, standardized regression coefficient.

^*Age, education, ACC, and PCC were entered as continuous variables. APOE4 was coded as the number of epsilon 4 alleles (0, 1, or 2). Sex was coded as 0 and 1 for female and male, respectively; ^†R²=0.062, p=0.008; ^‡R²= 0.108, p=0.005.