Table 1.
GBM LTS Patient and Second Primary Cancer Characteristics
| Patient No. | Sex | Age at GBM Diagnosis, y | OS from GBM Diagnosis, y | GBM Treatment | Age at Second Primary Cancer Diagnosis, y | Second Primary Cancer Pathology | Second Primary Cancer Location | Second Primary Cancer Treatment | Outcome (at Time of Analysis) |
| 1 | F | 36 | 14.3 | GTR, standard chemoradiation | 39 | Melanoma | Left fifth toe | Resection, amputation of toe | Died from GBM |
| 2 | M | 61 | 8.3 | GTR, standard chemoradiation | 69 | Leukemia | Systemic | High-dose chemotherapy | Died from leukemia |
| 3 | M | 63 | 6.2 | GTR, standard chemoradiation | 67 | Prostate cancer | Prostate | Radiation therapy and chemotherapy | Died from GBM |
| 4 | M | 54 | 6.5 | STR, upfront 4 cycles of 5-day TMZ, standard radiation alone | 61 | Squamous cell carcinoma | Right eyebrow | Biopsy | Died from pulmonary embolism |
| 61 | Basal cell carcinoma | Right earlobe | Biopsy | ||||||
| 61 | Basal cell carcinoma | Right posterior auricular | Biopsy | ||||||
| 5 | M | 60 | 7 | GTR, standard chemoradiation | 63 | Prostate cancer | Prostate | Cryotherapy | Died from GBM |
| 6 | F | 26 | NA | GTR, standard chemoradiation | 38 | Undifferentiated sarcoma | Scalp | Resection | Alive |
| 30 | Malignant melanoma | Right forearm | Resection | ||||||
| 7 | M | 48 | 6.6 | GTR with carmustine wafer, standard chemoradiation | 54 | Oligodendroglioma (WHO grade II) | Brain | Chemotherapy (daily TMZ) | Died from GBM |
| 8 | M | 44 | NA | GTR, standard radiation | 54 | Basal cell carcinoma | Right ear | Resection | Alive |
| 9 | F | 59 | NA | GTR, standard chemoradiation | 66 | Breast cancer | Breast | Lumpectomy and anastrozole | Alive |
| 69 | Basal cell carcinoma | Left cheek | Resection | ||||||
| 10 | M | 62 | 11.7 | GTR, clinical trial followed by standard radiation | 71 | Renal cell carcinoma | Kidney | Nephrectomy | Died from GBM |
| 11 | M | 54 | 7.8 | GTR, radiation alone followed by chemotherapy | 61 | B cell acute lymphocytic leukemia | Systemic | Chemotherapy | Died from leukemia |
| 12 | M | 66 | 7.4 | GTR, radiation alone followed by chemotherapy | 70 | Bladder cancer | Bladder | Resection | Died from GBM |
| 13 | F | 55 | 12.2 | GTR with carmustine wafer, standard chemoradiation | 66 | Grade I endometrioid adenocarcinoma | Endometrium | Hysterectomy | Died from GBM |
Abbreviations: F, female; GBM, glioblastoma; GTR, gross total resection; LTS, long-term survivors; M, male; NA, not available; OS, overall survival; standard chemoradiation, concurrent temozolomide and radiation; STR, subtotal resection; TMZ, temozolomide.