Table 4.

Plasma BDNF by WHO grade and NHPA Score

Glioma Grade	Plasma BDNF(pg/ml)
	NHPA (≤4)	NHPA (5-6)	P Value
WHO II and III	885.28 (9/47)	785.39 (38/47)	.1508
WHO IV	742.56 (14/75)	1114.21 (61/75)	.0473

Abbreviations: BDNF, brain-derived neurotrophic factor; NHPA, number of high-performance alleles.

Plasma BDNF levels are significantly higher in the high-performing NHPA 5-6 patients relative to the low-performing NHPA ≤4 group; however, this difference is observed only in WHO IV glioma patients rather than in patients with WHO II-III lower-grade glioma.