Table 5.

Plasma BDNF by WHO Grade and BDNF Genotype

Glioma Grade	Plasma BDNF (pg/ml)
	BDNF Val/Val	BDNF Val/Met	P Value
WHO II and III	693.36 (31/47)	1122.03 (16/47)	.1366
WHO IV	1354.59 (52/75)	344.52 (23/75)	.0471

Abbreviations: BDNF, brain-derived neurotrophic factor; Met, methionine; Val, valine.

Plasma BDNF levels are significantly higher in the BDNF Val/Met patients relative to the BDNF Val/Val patients; however, this difference is observed only in WHO IV glioma patients rather than in patients with WHO II-III lower-grade glioma.