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Digested-B. abortus RNA is also able to down-modulate MHC-II. THP-1 cells were treated with B. abortus RNA (10 μg/ml) or RNase I-treated B. abortus RNA in the presence of IFN-γ for 48 h. Cells treated with RNase I were used as a control. MHC-II expression was assessed by flow cytometry. Bars represent the arithmetic means ± SEM of five independent experiments. MFI, mean fluorescence intensity; ns, non-significant. ***P < 0.001 vs. IFN-γ-treated cells.
