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. 2019 Sep 13;6:138. doi: 10.3389/fcvm.2019.00138

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Copyright © 2019 Lesyk and Jurasz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A cartoon summarizing the “seed platelet” hypothesis in which NO-refractory eNOS^neg platelets preferentially initiate platelet adhesion and aggregation, while eNOS^pos platelets form the bulk of an aggregate and limit its size. Figure S21. Radziwon-Balicka et al. (47), by permission of Oxford University Press. MMP-2, matrix metalloproteinase-2; NO, nitric oxide, TXA₂, Thromboxane A₂.