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. 2019 Sep 13;10:1015. doi: 10.3389/fphar.2019.01015

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Copyright © 2019 Orejudo, Rodrigues-Diez, Rodrigues-Diez, Garcia-Redondo, Santos-Sánchez, Rández-Garbayo, Cannata-Ortiz, Ramos, Ortiz, Selgas, Mezzano, Lavoz and Ruiz-Ortega

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Systemic infusion of IL-17A in mice increases renal expression of proinflammatory factors. Evaluation of gene expression of proinflammatory factors (A) and kallikrein-1 (B) in the kidney of IL-17A-infused and control mice evaluated by real-time PCR gene. In paraffin-embedded sections, kallikrein-1 was evaluated by immunohistochemistry. (C). Quantification of the staining. Figure (D) shows representative images of light microscopy showing positive tubular staining in IL-17A-infused mice. Data are expressed as mean ± S.E.M. of 6–8 mice per group. *p < 0.05 vs. control.