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IL-17A administration in mice does not induce renal fibrosis within the time-course of the study. (A) In IL-17A-infused mice, the gene expression of profibrotic factors and ECM components was evaluated by real-time PCR. Collagen accumulation was evaluated in paraffin-embedded sections stained with Sirius Red. Figure (B) shows a representative mouse kidney and in (C) quantification. Data are expressed as mean ± S.E.M. of 6–8 mice per group. *p < 0.05 vs. control.
