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. 2019 Sep 13;10:1015. doi: 10.3389/fphar.2019.01015

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Copyright © 2019 Orejudo, Rodrigues-Diez, Rodrigues-Diez, Garcia-Redondo, Santos-Sánchez, Rández-Garbayo, Cannata-Ortiz, Ramos, Ortiz, Selgas, Mezzano, Lavoz and Ruiz-Ortega

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of IL-17A neutralization on renal morphology and fibrosis in the model of angiotensin II infusion in mice. Mice were infused with 1,000 ng/kg/min angiotensin II (Ang II) for 14 days, treated or not with a neutralizing antibody against IL-17A (100 µg/mouse i.p. every 4 days), and compared with control mice. (A) Kidney sections were stained with PAS and picrosiruis red. Figures show representative images of light microscopy. Magnification ×200. The quantification of renal lesion (B), inflammatory infiltration (C), and collagen (D) is also shown. Data are expressed as mean ± S.E.M. of 6–8 mice per group. *p < 0.05 vs. Control. ^#p < 0.05 vs. AngII-infused mice.