Table 1.

Criteria for selecting predicted Pathogenic SNPs.

Protein prediction algorithm	Cutoff-Value	Interpretation
SIFT	D	D:Delterious(sift< = 0.05)
PolyPhen 2 HDIV	D	D:Probably damaging(> = 0.957)
PolyPhen 2 Hvar	D	D:Probably damaging(> = 0.909)
CADD	Score >25	10 means 10% percentile highest scores; 20 means 1% percentile highest scores; 30 means 0.1% percentile highest scores
GERP++	Score >5	High scores are more deleterious