Table 2. Clinical outcomes.

Outcome	Pre-protocol (n=72)	Post-protocol (n=51)	P value
Major bleeding	50 (69.4)	34 (66.7)	0.85
Hgb drop ≥4 g/dL	10 (13.9)	5 (9.8)	0.50
>2 pRBC units/day	48 (66.7)	34 (66.7)	1.00
Retroperitoneal bleed	11 (15.3)	1 (2.0)	0.01
Pulmonary or CNS bleed	10 (13.9)	2 (3.9)	0.07
Surgical intervention	9 (12.5)	3 (5.9)	0.22
Minor bleeding	6 (8.3)	5 (9.8)	0.78
Thrombosis	15 (20.8)	14 (27.5)	0.39
Circuit thrombosis	8 (11.1)	9 (17.6)	0.30
DIC	6 (8.3)	7 (13.7)	0.34
Ischemic stroke	4 (5.6)	1 (2.0)	0.32
Pulmonary embolism	1 (1.4)	0 (0.0)	0.40
Deep vein thrombosis	3 (4.2)	0 (0.0)	0.14
Arterial thrombosis	3 (4.2)	1 (2.0)	0.50
ICU length of stay (days)	23.5±43.5	21.4±18.2	0.80
Mortality (in-hospital)	52 (72.2)	29 (56.9)	0.07
Mortality (on ECMO)	41 (56.9)	17 (33.3)	0.01

Data are presented as mean ± SD or as n (%). Hgb, hemoglobin; pRBC, packed red blood cells; CNS, central nervous system; DIC, disseminated intravascular coagulation; ICU, intensive care unit; ECMO, extracorporeal membrane oxygenation; SD, standard deviation.