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. 2019 Sep 13;6:88. doi: 10.3389/fmolb.2019.00088

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Copyright © 2019 McQuillan, Byrd-Leotis, Heimburg-Molinaro and Cummings.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influenza A virus binding to CFG array. The strength of IAV binding to each glycan on the CFG array is visualized by the force plot, where bound glycans are linked to the IAV spot (magenta) in the middle and unbound glycans are pushed to the periphery. Neu5Ac and Neu5Gc sialylated glycans are highlighted in blue and green, respectively. The structures corresponding to one example each of Neu5Ac and Neu5Gc terminating glycans are displayed and the binding to each structure is highlighted on the bar chart comparing RFU. Glycan cartoon key: light blue diamond- Neu5Gc, purple diamond- Neu5Ac, yellow circle- Gal, blue square- GlcNAc, green circle- Man, red triangle- Fuc, black circle- linker. Figure produced using the GLycan Array Dashboard (GLAD) program, developed by the Cummings group (Mehta and Cummings, 2019), website- https://glycotoolkit.com/Tools/GLAD/.