Table 1.
Day 1 | Day 2 | Day 3 | Day 6 | Day 7 | |
---|---|---|---|---|---|
Day 0, challenge 1 | |||||
control | 3.6 × 104 | 3.9 × 105 | 7.5 × 106 | 4.8 × 107 | 4.8 × 108 |
test 1 | 0 | 0 | 0 | 0 | 0 |
test 2 | 0 | 0 | 0 | 0 | 0 |
test 3 | 0 | 0 | 0 | 0 | 0 |
Day 0, challenge 2 | |||||
control | 2.8 × 104 | 7.5 × 106 | 1.5 × 107 | 4.5 × 107 | 1.1 × 108 |
test 1 | 0 | 0 | 0 | 0 | 0 |
test 2 | 0 | 0 | 0 | 0 | 0 |
test 3 | 0 | 0 | 0 | 0 | 0 |
Day 0, challenge 3 | |||||
control | 3.9 × 105 | 3.6 × 106 | 2.5 × 107 | 2.1 × 107 | 1.0 × 108 |
test 1 | 0 | 0 | 0 | 0 | 0 |
test 2 | 0 | 0 | 0 | 0 | 0 |
test 3 | 0 | 0 | 0 | 0 | 0 |
Day 0, challenge 4 | |||||
control | 2.5 × 105 | 6.5 × 106 | 6.6 × 107 | 2.5 × 108 | 1.1 × 108 |
test 1 | 0 | 0 | 0 | 0 | 0 |
test 2 | 0 | 0 | 0 | 0 | 0 |
test 3 | 0 | 0 | 0 | 0 | 0 |
A value of 0 corresponds to a value that was below the lower limit of detection.
The negative cultures remained in the antimicrobial catheters throughout the four weekly challenges and each post-challenge perfusion (7 days).