. 2019 Jul 12;74(10):3003–3010. doi: 10.1093/jac/dkz298

Table 2.

Statistically significant results from univariate and multivariate linear regression analysis within each study group

	Univariate linear regression			Multivariate linear regression
	P	β (95% CI)	r ²	P	β (95% CI)	r ²
Efavirenz group
log₁₀ ENG C_max
CYP2B6 516G>T (rs3745274)	0.135	−0.085 (−0.2, 0.0)	0.126
CYP2B6 983T>C (rs28399499)	0.014	−0.222 (−0.4,−0.5)	0.307	0.003	−0.237 (−0.4, 0.1)	0.518
CYP2B6 15582C>T (rs4803419)	0.070	−0.277 (−0.6, 0.3)	0.180
ABCB1 4036A>G (rs3842)	0.110	0.068 (0.0, 0.2)	0.144
ENG T_max
log₁₀ weight (log₁₀ kg)	0.199	3.005 (−1.7, 7.8)	0.095
CYP2B6 516G>T (rs3745274)	0.045	0.507 (0.0, 1.0)	0.216	0.045	0.507 (0.0, 1.0)	0.216
log₁₀ ENG C_min
CYP2B6 516G>T (rs3745274)	0.003	−0.102 (−0.2, 0.0)	0.423	0.003	−0.102 (−0.2, 0.0)	0.423
log₁₀ ENG AUC_0–24weeks
CYP2B6 516G>T (rs3745274)	0.028	−0.098 (−0.2, 0.0)	0.255	0.008	−0.106 (−0.2, 0.0)	0.487
CYP2B6 983T>C (rs28399499)	0.062	−0.142 (−0.3, 0.0)	0.190	0.016	−0.158 (−0.3, 0.0)	0.487
Nevirapine group
log₁₀ ENG C_max
CYP2B6 983T>C (rs28399499)	0.013	0.187 (0.0, 0.3)	0.313	0.013	0.187 (0.0, 0.3)	0.313
NR1I2 63396C>T (rs2472677)	0.058	−0.091 (−0.2, 0.0)	0.196
log₁₀ ENG C_min
CYP2B6 983T>C (rs28399499)	0.062	0.114 (0.0, 0.2)	0.190
NR1I2 63396C>T (rs2472677)	0.010	−0.091 (−0.2, 0.0)	0.329	0.010	−0.091 (−0.2, 0.0)	0.028
log₁₀ ENG AUC_0–24weeks
CYP2B6 983T>C (rs28399499)	0.080	0.125 (0.0, 0.3)	0.170
CYP3A4 392G>A (rs2740574)	0.154	0.063 (−0.2, 0.0)	0.116	0.004	0.096 (−0.2, 0.0)	0.643
NR1I2 63396C>T (rs2472677)	0.004	−0.116 (−0.2, 0.0)	0.388	<0.001	−0.139 (−0.2,−0.1)	0.643
Control group
log₁₀ ENG C_max
CYP2B6 983T>C (rs28399499)	0.053	0.159 (0.0, 0.3)	0.203	0.013	0.193 (0.0, 0.3)	0.416
CYP3A4 392G>A (rs2740574)	0.133	0.063 (0.0, 0.1)	0.128	0.028	0.083 (0.0, 0.2)	0.416
log₁₀ ENG AUC_0–24weeks
CYP2B6 983T>C (rs28399499)	0.043	0.156 (0.0, 0.3)	0.219	0.011	0.188 (0.0, 0.3)	0.415
CYP3A4 392G>A (rs2740574)	0.160	0.056 (0.0, 0.1)	0.113	0.034	0.076 (0.0, 0.1)	0.415

ENG, etonogestrel.

Univariate linear regression (P ≤0.2) completed, all statistically significant results then carried through to multivariate linear regression analysis (P ≤0.05). All statistically significant variables from multivariate linear regression are shown in bold.