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. 2019 Jul 18;47(17):e102. doi: 10.1093/nar/gkz612

Scheme 1.

Scheme 1.

(A) The borate ion interacts with cis-diol (2′ and 3′ OH groups in ribose) of rNTP forming a rNTP–borate complex with a reversible borate ester. (B) A schematic diagram of the inhibitory pathway for rNTP incorporation in the TdT reaction influenced by Tris-borate buffer.