TABLE 2.
Clinical Characteristics of Patients Who Received SOF-Based Regimens for CHC Therapy in a U.S. Population with Commercial and Medicare Supplemental Insurance Plans,a 2013-2015
| Characteristics | SOF + SIM ± RBV (n = 1,761) | SOF + PEG + RBV (n = 1,314) | SOF + RBV (n = 1,994) | LED/SOF ± RBV (n = 5,739) |
|---|---|---|---|---|
| Treatment option with RBV, n (%) | ||||
| No | 1,506 (85.5) | NA | NA | 5,470 (95.3) |
| Yes | 255 (14.5) | 269 (4.7) | ||
| Liver disease severity, n (%) | ||||
| Noncirrhotic disease | 1,330 (75.5) | 1,086 (82.6) | 1,612 (80.8) | 5,094 (88.8) |
| Compensated cirrhosis | 243 (13.8) | 173 (13.2) | 204 (10.2) | 422 (7.4) |
| Decompensated cirrhosis | 188 (10.7) | 55 (4.2) | 178 (8.9) | 223 (3.9) |
| Liver cancer, n (%) | ||||
| No | 1,709 (97.0) | 1,305 (99.3) | 1,944 (97.5) | 5,674 (98.9) |
| Yes | 52 (3.0) | 9 (0.7) | 50 (2.5) | 65 (1.1) |
| Liver transplant, n (%) | ||||
| No | 1,663 (94.4) | 1,293 (98.4) | 1,935 (97.0) | 5,653 (98.5) |
| Yes | 98 (5.6) | 21 (1.6) | 59 (3.0) | 86 (1.5) |
| HIV coinfection, n (%) | ||||
| No | 1,734 (98.5) | 1,291 (98.2) | 1,960 (98.3) | 5,639 (98.3) |
| Yes | 27 (1.5) | 23 (1.8) | 34 (1.7) | 100 (1.7) |
| CCI score, n (%) | ||||
| 0 | 1,214 (68.9) | 966 (73.5) | 1,463 (73.4) | 4,769 (83.1) |
| 1 | 231 (13.1) | 219 (16.7) | 263 (13.2) | 527 (9.2) |
| ≥ 2 | 316 (17.9) | 129 (9.8) | 268 (13.4) | 443 (7.7) |
| CCI | ||||
| Mean ± SD | 0.83 ± 1.65 | 0.53 ± 1.29 | 0.69 ± 1.57 | 0.41 ± 1.21 |
| Median: min, max | 0: 0, 13 | 0: 0, 14 | 0: 0, 12 | 0: 0, 13 |
| History of alcohol dependence/abuse, n (%) | ||||
| No | 1,717 (97.5) | 1,292 (98.3) | 1,947 (97.6) | 5,673 (98.8) |
| Yes | 44 (2.5) | 22 (1.7) | 47 (2.4) | 66 (1.2) |
| History of injection/noninjection drug abuse, n (%) | ||||
| No | 1,717 (97.5) | 1,249 (95.1) | 1,924 (96.5) | 5,619 (97.9) |
| Yes | 44 (2.5) | 65 (4.9) | 70 (3.5) | 120 (2.1) |
aClinical conditions were summarized using available claims data 1 year before the index date. The index date was the first prescription date for SIM, SOF, or LED/SOF. CCI = Charlson Comorbidity Index; CHC = chronic hepatitis C; HIV = human immunodeficiency virus; LED = ledipasvir; max = maximum; min = minimum; NA = not applicable; PEG = pegylated interferon alpha-2a or 2b; RBV = ribavirin; SD = standard deviation; SIM = simeprevir; SOF = sofosbuvir.