Table 2. Associations between schizophrenia polygenic risk (pT 0.05) and sleep outcomes.
Sleep phenotype (units) | Beta or OR | 95% CI | R-squared 1 | P-value |
---|---|---|---|---|
Sleep duration in children (seconds) 2 | -44.52 | -88.98, -0.07 | 0.0002 | 0.05 |
Nightmares in children (ordinal, OR) | 1.08 | 1.01, 1.14 | 0.001 | 0.02 |
Sleep duration in mothers (seconds) | -49.97 | -150.48, 50.55 | 0.0003 | 0.33 |
1The r-squared values were a marginal r-squared (the proportion of variance explained by the fixed effects) for sleep duration in children, Nagelkerke’s pseudo r-squared for nightmares and the r-squared for sleep duration in mothers. 2For this analysis we combined all time points into one stacked dataset in a linear mixed-effects model, resulting in 28,138 data points in the model.