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. 2019 Sep 13;10:2160. doi: 10.3389/fmicb.2019.02160

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Copyright © 2019 Toro, Mestre, Martínez-Abarca and González-Delgado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogeny of RTCas1/Cas1 and Cas2 proteins associated with clade 2 Cas13a sequences. The unrooted trees were constructed with FastTree from alignments of 99 closely related Cas1 sequences (A), and 537 closely related Cas2 sequences (B) mostly harbored by bacteria from phylum Firmicutes. The Cas1 and Cas2 sequences and their associated CRISPR-Cas loci are shown in Supplementary Tables S3, S4, respectively. The Cas1 and Cas2 tree newick files are provided as Supplementary Files S2, S3, respectively. Branches in red indicate the RT-Cas1 and adjacent Cas2 sequences associated with Cas13a proteins in type VI-A/RT2 systems, and branches in blue show Cas1 sequences lacking an RT domain and Cas2-associated sequences within clade 2. Other identified CRISPR-Cas systems, classified according to the interference module, are also specified.