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. 2019 Sep 13;10:2189. doi: 10.3389/fimmu.2019.02189

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Copyright © 2019 Lee, Lao-araya, Yang, Chan, Ma, Pei, Kui, Mao, Yang, Zhao, Trakultivakorn and Lau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PBMCs were stimulated with IFN-α (40,000 IU/ml) followed by treatment with staurosporine (500 nM) for 30 min, and analyzed for intracellular pSTAT1 expression by gating on CD3+ T-cells. The increase in %pSTAT1⁺ population in stimulated cells relative to unstimulated cells was calculated. (A) Representative histograms are shown for Patients F5.1 and F5.2 and 3 healthy controls. (B) %pSTAT1⁺ T-cells (i) and mean fluorescent intensity (MFI) (ii) in Patients F5.1 and F5.2 compared with 3 healthy controls. Data expressed as mean ± SEM.