Table 1.

Summary of referenced studies addressing immunomodulatory and neuroprotective effects of exercise in MS animal models.

		MS animal model	Effects of exercise on adaptive immune system	Effects of exercise on innate immune system	Effects of exercise on brain inflammation	Effects of exercise on brain neurotrophins	Other effects of exercise or only effects on clinical score
Forced exercise	Preventive	EAE	37; 38; 39; 42; 43;44	37; 38; 39; 47	36; 37; 42; 43; 44	36; 37; 42; 43; 44	34; 35
		CPZ		40		40	41
	Therapeutic	EAE				45; 46
Environmental enrichment	Preventive	EAE	50; 51		49		48; 50
		LPC					48
Voluntary exercise	Preventive	EAE	51; 52; 53; 54	53; 54
		CPZ		56
		LPC		55
	Therapeutic	EAE				46