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. 2019 Sep 13;10:986. doi: 10.3389/fphar.2019.00986

Figure 4.

Figure 4

GA and NGA can effectively inhibit septicemic and skin infection caused by S. aureus ATCC33591 in vivo. (A) Fifteen mice per group were infected (i.p) with non-lethal dose of S. aureus ATCC33591 and treated orally with GA, NGA, vancomycin (5 mg/kg) or the vehicle alone for six days (one dose per day). 24 h after the last treatment, mice were euthanized and their organs were excised and homogenized in TSB to count viable MRSA colonies. The number of CFU from each mouse is plotted as individual points. Values are the mean of triplicate results with standard deviation bars. (B) Histological evaluation of lung and liver of mice infected with S. aureus ATCC33591 receiving no treatment or a treatment with GA and NGA. Both lung and liver in control group demonstrated acute inflammation, in the treated, group no apparent pathological changes were observed. (C) Ten mice per group with subcutaneous infection S. aureus ATCC33591. After the wound is formed the mice were treated with 1% GA or 1% NGA once a day for 9 d. Compared with the control group, the wounds healed well after GA and NGA treatment, the wound area (D) and the amount of bacteria (E) were significantly reduced.