Table 1. Differentially proteins identified on day 13 and day 21.

Uniprot ID	Human ortholog	Description	Trends	ANOVA P-value	Average fold change
					Day 13	Day 21
P02761	NO	Cluster of Major urinary protein	↑	<0.00010	4.70	7.59
P06760	P08236	Beta-glucuronidase	↑	0.0073	3.56	4.55
Q9JI85	P80303	Nucleobindin-2	↑	0.00018	2.74	3.69
P27590	P07911	Uromodulin	↑	<0.00010	2.31	2.65
P97603	Q92859	Neogenin (Fragment)	↓	<0.00010	0.43	0.21
P20611	P11117	Lysosomal acid phosphatase	↓	<0.00010	0.56	0.46
Q9ESS6	P50895	Basal cell adhesion molecule	↓	<0.00010	0.56	0.40
Q63556	NO	Serine protease inhibitor A3M (Fragment)	↓	<0.00010	0.47	0.48
O35112	Q13740	CD166 antigen	↓	<0.00010	0.41	0.33
Q63416	Q06033	Inter-alpha-trypsin inhibitor heavy chain H3	↓	<0.00010	0.32	0.23
O70535	P42702	Leukemia inhibitory factor receptor	↓	<0.00010	0.29	0.35
P13596	P13591	Neural cell adhesion molecule 1	↓	<0.00010	0.28	0.36
P35444	P49747	Cartilage oligomeric matrix protein	↓	<0.00010	0.27	0.42
P07897	P16112	Aggrecan core protein	↓	<0.00010	0.23	0.30
P26453	P35613	Basigin	↓	0.00094	0.23	0.21
Q9EPF2	P43121	Cell surface glycoprotein MUC18	↓	<0.00010	0.18	0.08
P38918	O95154	Aflatoxin B1 aldehyde reductase member 3	↑	0.0028	3.36	–
Q63530	Q96BW5	Phosphotriesterase-related protein	↑	0.0004	3.18	–
P24268	P07339	Cathepsin D	↑	<0.00010	1.56	–
P18292	P00734	Prothrombin	↓	<0.00010	0.60	–
P04937	P02751	Fibronectin	↓	<0.00010	0.61	–
P08592	NO	Amyloid beta A4 protein	↓	<0.00010	0.56	–
Q91XN4	Q13145	BMP and activin membrane-bound inhibitor homolog	↓	0.003	0.55	–
Q9JLS4	Q6FHJ7	Secreted frizzled-related protein 4	↓	0.00053	0.52	–
Q63467	P04155	Trefoil factor 1	↓	0.00026	0.50	–
Q62930	P02748	Complement component C9	↓	0.0055	0.49	–
P24090	P02765	Alpha-2-HS-glycoprotein	↓	0.00026	0.47	–
P97546	Q9Y639	Neuroplastin	↓	<0.00010	0.47	–
P26644	P02749	Beta-2-glycoprotein 1	↓	0.00016	0.46	–
Q5HZW5	Q9NPF0	CD320 antigen	↓	<0.00010	0.45	–
Q8JZQ0	P09603	Macrophage colony-stimulating factor 1	↓	0.00013	0.42	–
P07154	P07711	Cathepsin L1	↓	0.00021	0.40	–
D3ZTE0	P00748	Coagulation factor XII	↓	<0.00010	0.25	–
P07171	P05937	Cluster of Calbindin	↓	<0.00010	0.05	–
Q63475	Q92932	Receptor-type tyrosine-protein phosphatase N2	↓	<0.00010	–	6.25
P00714	P00709	Alpha-lactalbumin	↑	<0.00010	–	3.77
Q05175	P80723	Brain acid soluble protein 1	↑	<0.00010	–	3.69
Q4V885	Q5KU26	Collectin-12	↑	0.0011	–	2.28
O55004	P34096	Ribonuclease 4	↑	0.00023	–	2.13
P81828	NO	Urinary protein 2	↑	<0.00010	–	1.96
P62986	P62987	Ubiquitin-60S ribosomal protein L40	↑	0.0011	–	1.81
P36374	NO	Prostatic glandular kallikrein-6	↑	0.0034	–	1.78
P80202	P36896	Activin receptor type-1B	↑	<0.00010	–	1.76
P06866	P00739	Haptoglobin	↑	0.00036	–	1.68
P07151	P61769	Beta-2-microglobulin	↑	<0.00010	–	1.65
P08937	NO	Odorant-binding protein	↑	0.002	–	1.51
P05544	NO	Serine protease inhibitor A3L	↓	0.00026	–	0.64
P29598	P00749	Urokinase-type plasminogen activator	↓	<0.00010	–	0.62
P05545	NO	Serine protease inhibitor A3K	↓	<0.00010	–	0.61
Q01460	Q01459	Di-N-acetylchitobiase	↓	<0.00010	–	0.61
Q642A7	Q8WW52	Protein FAM151A	↓	0.00045	–	0.58
P21704	P24855	Deoxyribonuclease-1	↓	<0.00010	–	0.56
P63018	P11142	Cluster of Heat shock cognate 71 kDa protein	↓	0.00045	–	0.56
P61972	P61970	Nuclear transport factor 2	↓	0.0024	–	0.54
Q68FQ2	Q9BX67	Junctional adhesion molecule C	↓	0.0011	–	0.53
P31211	P08185	Corticosteroid-binding globulin	↓	0.00011	–	0.48
Q9R0T4	P12830	Cadherin-1	↓	<0.00010	–	0.47
Q562C9	Q9BV57	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	↓	0.0057	–	0.43
O88917	NO	Adhesion G protein-coupled receptor L1	↓	<0.00010	–	0.42
Q9WUW3	P05156	Complement factor I	↓	<0.00010	–	0.42
P01026	P01024	Complement C3	↓	0.0071	–	0.42
P85971	O95336	6-phosphogluconolactonase	↓	0.0005	–	0.39
Q63751	NO	Vomeromodulin (Fragment)	↓	0.012	–	0.31
Q9EQV6	O14773	Tripeptidyl-peptidase 1	↓	0.0033	–	0.30
P53813	P07225	Vitamin K-dependent protein S	↓	0.00096	–	0.29
Q00657	Q6UVK1	Chondroitin sulfate proteoglycan 4	↓	<0.00010	–	0.28
P04073	P20142	Gastricsin	↓	0.00044	–	0.27
O70244	O60494	Cubilin	↓	<0.00010	–	0.25
Q1WIM1	Q8NFZ8	Cell adhesion molecule 4	↓	<0.00010	–	0.24
Q5I0D5	Q9H008	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	↓	<0.00010	–	0.20
Q63678	P25311	Zinc-alpha-2-glycoprotein	↓	<0.00010	–	0.20
Q99PW3	Q99519	Sialidase-1	↓	0.00025	–	0.18
Q641Z7	Q92484	Acid sphingomyelinase-like phosphodiesterase 3a	↓	<0.00010	–	0.18
P04785	P07237	Protein disulfide-isomerase	↓	<0.00010	–	0.17
Q6AYE5	Q86UD1	Out at first protein homolog	↓	<0.00010	–	0.16
P47820	P12821	Angiotensin-converting enzyme	↓	0.0016	–	0.13
Q80WD1	Q86UN3	Reticulon-4 receptor-like 2	↓	0.017	–	0.04