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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Clin Pharmacol Ther. 2018 Aug 6;105(1):210–218. doi: 10.1002/cpt.1146

Table 4.

Operational definition of the outcome of interest and performance measure of the ascertainment algorithm

Outcome ICD-9-CM code Diagnosis description Diagnosis position
and claim type
Performance
of algorithm
Serious hypoglycemia 251.0 hypoglycemic coma Any position of discharge diagnosis on ED claim or principal position on inpatient claim PPV ~89%23 (ED claim); 78%24 (inpatient claim)
251.1 other specific hypoglycemia
251.2 hypoglycemia, unspecified
250.8X diabetes with other specified manifestations
Exclusionary diagnosis codes in the occurrences of 250.8X23-24
259.8 Other specified endocrine disorders Secondary diabetic glycogenosis Any position of discharge diagnosis on ED claim or principal position on inpatient claim
272.7 Mixed hyperlipidemia Diabetic lipidosis
681.XX Cellulitis and abscess of finger and toe Cellulitis
682.XX Other cellulitis and abscess
686.9 Unspecified local infection of skin and subcutaneous tissue
707.1X Ulcer of lower limbs, except decubitus ulcer Ulcers of the lower extremity
707.2X Pressure ulcer stages
707.8 Chronic ulcer of other specified sites
707.9 Chronic ulcer of unspecified site
709.3 Degenerative skin disorders Necrobiosis lipoidica diabeticorum
730.0X Acute osteomyelitis Osteomyelitis
730.1X Chronic osteomyelitis
730.2X Unspecified osteomyelitis
731.8 Other bone involvement in diseases classified elsewhere

ED: emergency department. ICD-9-CM: International Classification of Diseases, 9th Revision, Clinical Modification. PPV: positive predictive value.