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. 2019 Sep 4;2(9):e1910626. doi: 10.1001/jamanetworkopen.2019.10626

Figure 2. Trends in Varenicline and Nicotine Replacement Therapy (NRT) Use in the Veterans Health Administration, October 1, 2001, to December 31, 2018.

Figure 2.

Number of unique patients using varenicline and NRT every quarter in the Veterans Health Administration. Values were estimated with interrupted time series analyses. Period 1 indicates the time before the publication of the US Food and Drug Administration (FDA) public health advisory on February 1, 2008; period 2, the time between the publication of the FDA public health advisory and the removal of the boxed warning on December 16, 2016; and period 3, the time after the removal of the boxed warning.