Histopathology of mouse EAU compared with human uveitis. Eyes were collected from B10.RIII mice before (a) and 21 days after uveitogenic immunization with IRBP (b). Note disorganized retinal architecture and damage to ganglion and photoreceptor cell layers, retinal folds, subretinal hemorrhage, vasculitis, focal damage to the retinal pigment epithelium, and choroiditis. Uveitis in the patient with ocular sarcoidosis (c). Note gross similarity in pathological picture between b and c (Photographs provided by Dr. Chi-Chao Chan, Laboratory of Immunology, National Eye Institute) (Reprinted from ref. 9)