Table 10.

Summary and dosage of reversal agents for platelet inhibitors—aspirin, clopidogrel, prasugrel, ticagrelor and nonsteroidal anti-inflammatory drugs.

Agent	Dose	Additional Information
Platelet transfusion	2–3 U of pooled platelets or 2–3 Apheresis U	Human studies proving the efficacy of the use of platelets in patients with anti-platelet agent induced bleeding are lacking.
DDAVP (Desmopressin)	0.4 μg/kg IV	Promotes platelet adherence. Consider for bleeding with platelet inhibitor use along with platelet transfusion.

U, unit; μg/kg IV, micrograms per kilogram intravenously.