. 2019 Aug 6;20(5):770–783. doi: 10.5811/westjem.2018.5.38235

Table 3.

Summary and dosage of reversal agents for warfarin in life-threatening bleeding.

Agent	Dose	Additional Information
Vitamin K	1–10 mg IV	SC delivery is no longer used
PCC 3-Factor (Profilnine) 4 factor (Kcentra^*)	Strategy 1: INR and Weight-Based Dosing INR 2–4: 25 IU/kg by IV push INR ≥4–6: 35 IU/kg by IV push INR >6: 50 IU/kg by IV push Strategy 2: INR-Based Dosing INR <5: 500 units; INR ≥5: 1000 units Strategy 3: Fixed Dose 1500 IU	INR-based dosing is most effective with 3-factor preparations. Absolute dosing strategies should not be used with 3-factor PCCs. Any of the 3 strategies can be used with 4-factor PCCs.

Agent

Dose

Additional Information

Vitamin K

1–10 mg IV

SC delivery is no longer used

PCC
3-Factor (Profilnine)
4 factor (Kcentra^*)

Strategy 1: INR and Weight-Based Dosing

INR 2–4: 25 IU/kg by IV push
INR ≥4–6: 35 IU/kg by IV push
INR >6: 50 IU/kg by IV push

Strategy 2: INR-Based Dosing

INR <5: 500 units; INR ≥5: 1000 units

Strategy 3: Fixed Dose

1500 IU

INR-based dosing is most effective with 3-factor preparations.
Absolute dosing strategies should not be used with 3-factor PCCs.
Any of the 3 strategies can be used with 4-factor PCCs.

mg, milligram; SC, subcutaneous; PCC, prothrombin complex concentrate; INR, international normalized ratio; IU, international unit; IV, intravenous; kg, kilogram.

U.S. Food and Drug Administration-approved for the reversal of warfarin-related bleeding.