Table 5.

Dosage of reversal agents for dabigatran.

Agent	Dose	Additional Information
aPCC (FEIBA)	50 U/kg	May be more thrombogenic than non-activated PCC.
Antibodies to dabigatran (Idarucizumab)	5 g provided as two separate vials each containing 2.5 g/50 mL.	The only FDA-approved “antidote” to dabigatran-related bleeding.
Cryoprecipitate	2 bags	If fibrinogen is < 200 mg/dL, give 2 bags cryoprecipitate.

aPCC, activated prothrombin complex concentrate; FEIBA, factor VIII inhibitor bypassing activity; U/kg, units per kilogram; g, gram; mL, milliliter; FDA, U.S. Food and Drug Administration; mg/dL, milligrams per deciliter.