Table 6.

Dosage of nonspecific reversal agents for anti factor Xα anticoagulants (rivaroxaban, apixaban, edoxaban, betrixaban).

Agent	Dose	Additional Information
4-Factor PCC (Kcentra)	25–50 units/kg	Not to exceed 5000 units. Repeat dosing is not recommended. This is generally considered the preferred agent for reversing anti-Xa Inhibitors.
aPCC (FEIBA)	25 units/kg	If still clinically significant bleeding, consider re-dosing, but no sooner than 6 hours.

aPCC, activated prothrombin complex concentrate; FEIBA, factor VIII inhibitor bypassing activity; U/kg, units per kilogram.