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Dosing of andexanet.
| Drug | Anti-Xα Dose | Time Since Last Dose | |
|---|---|---|---|
| <8 Hours or Unknown | ≥ 8 Hours | ||
|
|
|
|
|
| Rivaroxaban | ≤ 10 mg | Low Dose | Low Dose |
| > 10 mg or Unknown | High Dose | ||
| Apixaban | ≤ 5 mg | Low Dose | Low Dose |
| > 5 mg or Unknown | High Dose | ||
Low dose, 400 milligrams (mg) at 30 mg/min followed by 4 mg/min for up to 120 min; high dose, 800 mg over 30 mg/min followed by 8 mg/min (milligrams per minute) for up to 120 min.
