Table 1.

Baseline demographic characteristics of patients with and patients without MACE^a

Characteristic	No MACE (n = 4,024)	Adjudicated MACE (n = 52)
Age, mean ± SD years	52.7 ± 11.9	60.2 ± 10.4
Female, no. (%)	3,334 (82.9)	43 (82.7)
BMI, mean ± SD kg/m2	27.0 ± 6.4	29.2 ± 8.2
History of CHD, no. (%)	21 (0.5)	0 (0.0)
History of cardiac disorders, no. (%)b	199 (4.9)	4 (7.7)
History of diabetes mellitus, no. (%)c	307 (7.6)	8 (15.4)
Abnormal BP, no. (%)d	334 (8.3)	4 (7.7)
History of hypertension, no. (%)	1,358 (33.7)	30 (57.7)
Smoking status, no. (%)
Never	676 (16.8)	14 (26.9)
Current	678 (16.8)	11 (21.2)
Ex‐smokere	2,667 (66.3)	27 (51.9)
Concomitant medications
Glucocorticoids, no. (%)	1,909 (47.4)	18 (34.6)
Statins, no. (%)	420 (10.4)	12 (23.1)
NSAIDs, no. (%)	2,817 (70.0)	34 (65.4)
MTX, no. (%)	2,443 (60.7)	36 (69.2)
MTX dose, mean ± SD mg	15.0 ± 4.7	14.9 ± 4.0

^aMACE = major adverse cardiovascular event; BMI = body mass index; CHD = coronary heart disease; NSAIDs = nonsteroidal antiinflammatory drugs; MTX = methotrexate.

^bIncluding any of the Medical Dictionary for Regulatory Activities–coded terms: angina pectoris, arrhythmia, atrial flutter, atrial fibrillation, first‐degree atrioventricular block, left bundle branch block, cardiac failure, cardiac failure congestive, cardiac valve disease, cardiomegaly, cardiomyopathy, coronary artery disease, hypertensive cardiomyopathy, left ventricular hypertrophy, mitral valve incompetence, mitral valve prolapse, valve prolapse, myocardial infarction, palpitations, sinus bradycardia, sinus tachycardia, tachycardia, tachycardia paroxysmal, tricuspid valve incompetence, and ventricular extrasystole.

^cBased on both use of diabetes medication and medical history.

^dDefined as systolic blood pressure (BP) of >150 mm Hg or diastolic BP of >90 mm Hg.

^eDefined as those who had smoked previously but were not smokers at baseline.