Table 1.
Traditional Chinese Medicine On Gastric Cancer
| Ingredients of TCD | TCD | Experiment | Gastric cancer cell line and Experimental animal | Dosage | Event/Mechanism | Effect | Refs&PMID |
|---|---|---|---|---|---|---|---|
| Prescriptions | Xiaotan Sanjie recipe | In vivo | BALB/C nude mice (5×106 MKN-45) |
1.496g | VEGF-C and VEGFR-3 | Metastasis |
37 21425575 |
| Herbs | Luteolin | In vitro | MGC-803, HUVECs, Hs-746T | 10、20、30 μM (Main 30 μM) |
Suppressed Notch1-VEGF signaling Regulated NF-kB, AKT, and MMP-9 signaling |
Angiogenesis and VM formation Metastasis |
32 28655612 |
| Tanshinone IIA (TSN) | In vitro | SGC-7901 | 1、5、20 μg/L | Downregulation of FOXM1 | Proliferation and Migration |
50 28184921 |
|
| Baicalein | In vitro | SGC-7901, MKN45 | 15、30、60 μmol/L | Regulated Bcl-2 and Bax Mitochondrial pathway |
Growth arrest Apoptosis |
54 26918059 |
|
| In vivo | BALB/c nude mice (1×106 SGC-7901) |
15、50 mg/kg | |||||
| Baicalein | In vitro | SGC-7901 and MGC-803 | <80 µM | p38 | Invasion |
44 25502212 |
|
| Crude extracts | Coleusin factor (CF) | In vitro | BGC-823 | 25、50、100 μM | G0/G1 Decreased cyclinD1, Bcl-2, and Bcl-xL, increased the p53, p21, and Rb. |
Growth arrest Proliferation and Apoptosis |
12 21093146 |
| Berberine hydrochloride (BER) | In vitro | AGS | 15 μM | G2/M Enhanced IL −8 expression Affected ERK1/2, SAPK/JNK, JAK2 and AP-1 pathway |
Growth arrest Proliferation and Metastasis |
13 24063987 |
|
| Ailanthone | In vitro | SGC-7901 | 0.5、1、2、4、 8 µM | G2/M Bcl-2 and Bax |
Growth arrest Apoptosis |
14 None |
|
| Celastrus Orbiculatus extract (COE) | In vitro | AGS and BGC-823 | 160 mg/L | PI3K/Akt/mTOR/p70s6k pathway Induced the caspase-dependent mitochondrial pathway |
Proliferation Apoptosis |
20 28476678 |
|
| In vivo | Nude mice(GFP GC cells) | 40 mg/kg | |||||
| Xiaotan Sanjie decoction | In vitro | GCSCs and MKN-45 | 1. 46、2.92 and 5.84 g/mL | Notch-1、Hes1、VEGF and Ki-67 | Metastasis |
34 25278704 |
|
| In vivo | Sprague-dawley rats and nude mice (1×106 CD44+ and CD44- cells) |
1. 46、2.92 and 5.84 g/mL | |||||
| Yiqi Huayu Jiedu decoction | In vitro | MGC-803 | 2 mg/mL | TGF-β/Smad | Invasion and Metastasis |
39 28539961 |
|
| In vivo | BALB/C nude mice (5×106 MGC-803) |
4 g/mL, 2 g/mL | |||||
| Aqueous Huaier Extract | In vitro | SGC-7901 and MGC-803 | 0.1、 0.2、 0.3、 0.5 mg/mL (main 0.5 mg/mL) |
Decreased N-cadherin and vimentin | Metastasis |
48 29151976 |
|
| In vivo | Zebrafish (3×102 SGC-7901 labeled with CM-Dil) |
1 mg/m | |||||
| Celastrus Orbiculatus extract (COE) | In vitro | MGC-803 | 20、40、80 µg/mL | Promoted the expression of maspin Phosphoinositide 3-kinase/Akt/mTOR and MAPK signaling pathways | Apoptosis Invasion and Migration |
55 29387218 |
|
| Compounds | Matrines | In vitro | SGC-7901 | 0.25、0.5、1.0、2.0 mg/mL | G0/G1 Bax |
Growth arrest Apoptosis |
10 21519796 |
| Gambogic acid (GA) | In vitro | BGC-823 | 1.4 μM | Repressed hTERT transcriptional activity via c-Myc and Akt | Telomerase activity |
18 18226852 |
|
| Crocodile choline (CCL) | In vitro | BGC-823, MGC-803, SGC-7901, MKN28 and GES1 | 10、20、40、60 µg/mL | G2/M ΔΨm and ROS Notch pathway |
Growth arrest Apoptosis Proliferation and Metastasis |
22 28347224 |
|
| In vivo | BALB/C nude mice (1×106 BGC-823) |
100 mg/kg | |||||
| Ginsenoside | In vivo | BALB/C nude mice (5×106 NUGC-4-RFP) |
1 mg/kg | VEGF-C, VEGF-D and VEGFR-3 | Proliferation and Metastasis |
36 28314255 |
|
| Matrine | In vitro | BCG-823 | 50 μg/mL | Affected vasodilator-stimulated phosphoprotein (VASP) | Migration |
45 23685951 |
|
| Silibinin | In vitro | SGC-7901 | 50、100、200 μM | Decreased MMP-2 and MMP-9 | Migration and Invasion |
43 29344204 |
|
| Astragalus polysaccharide | In vitro | AGS | 200 μg/mL | Inhibited phosphorylated AKT (p-AKT) and MMP-9 | Metastasis |
49 29428665 |
|
| Naringenin | In vitro | SGC-7901 | 20、40、80 μM | Regulated AKT pathway | Proliferation, Apoptosis, Migration, and Invasion |
52 26960693 |
|
| Components | Piperlongumine (PL) | In vitro | AGS and HGC-27 | 5、7.5、10 μM (Main 7.5 μM) |
G2/M Mediated by ROS and involves GADD45α, XIAP, and CHOP. Suppressed STAT3 and TERT |
Growth arrest Proliferation and Apoptosis |
19 26874726 |
| In vivo | Nude mice (2×106 HGC-27) |
3.6 mg/kg | |||||
| Pseudolaric acid B (PAB) | In vitro | BGC-823 and MKN-45 | 0.5、 2、5 、10 μM (10 μM) |
Suppressed PI3K/AKT, ERK1/2 and mitochondrial signaling Regulated MMP-9, HIF 1α, VEGF, VEGFR2, E-Cadherin and Ezrin |
Apoptosis Metastasis |
21 28132880 |
|
| In vivo | BALB/C nude mice(1×106 BGC-823) | 30 mg/kg | |||||
| Curcumin | In vitro | BGC-823 | 15 μmol/L | Regulated JNK-MAPK signal pathway | Growth arrest |
61 25292057 |
|
| Curcumin | In vitro | MKN45, AGS, GES-1 | 3.125、6.25、12.5、25.0 、50.0 μmol/L | Regulated Cox-2 and NF-kB pathway | Growth arrest |
63 25884903 |
|
| (-) - patchouli alcohol (PA) | In vitro | GES-1 | 10 μM | Decreased IL-4,IL-2,TNF-alpha Increased IL-13 | Growth arrest |
64 27017292 |
|
| Curcumin | In vitro | GC-MSCs | 30 μmol/L | Inhibited NF-κB/VEGF signaling |
Angiogenesis and Metastasis |
33 29312505 |
|
| Green tea polyphenols | In vitro | MKN-28 | 10-4 M catechin equivalents | Inhibited MMP-2、MMP-9 | Migration and Invasion |
42 29450132 |
|
| Dehydroeffusol | In vitro | SGC-7901 and AGS | 12、24、48 μM | Regulated VE-cadherin and MMP-2 | Adhesion, Migration, and Invasion |
53 25982451 |
|
| In vivo | BALB/C nude mice (4×106 SGC-7901) |
40、120 μg |