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. 2019 Sep 16;14:7533–7548. doi: 10.2147/IJN.S218057

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© 2019 Ding et al.

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Humoral immune effects of Cap-nM2e VLPs.

Notes: (A) Scheme of immunization, virus infection and sampling. (B) M2e-specific IgG level (n=6). (C) M2e-specific IgG1 level. (D) M2e-specific IgG2a level (n=6). (E) Sera IgG to native M2e which expressed on IAV-infected MDCK cells (n=6). (F) PCV2-specific IgG level (n=6). (G) PCV2-specific IgG1 level (n=6). (H) PCV2-specific IgG2a level (n=6). (I) PCV2-specific neutralizing antibodies' level (n=6). p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), p < 0.0001 (****).

Abbreviations: Cap, Capsid; M2e, ectodomain of matrix protein 2; VLPs, virus-like particles; IAV, influenza A viruses; PCV2, porcine circovirus type 2; MDCK, Madin–Darby canine kidney; N.C. not compared.