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. 2019 Sep 20;9:13619. doi: 10.1038/s41598-019-49931-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Determining the antiviral efficacy of free HMW poly(I:C) and Nano-HMW against VHSV-IVa. RTgutGC cells grown in a monolayer were infected with viral hemorrhagic septicemia virus strain IVa (VHSV-Iva; MOI = 1) 6 hr after treatment with HMW poly(I:C) or Nano-HMW at 1000 ng/mL. Controls included cells treated with media alone (CTRL), cells treated with media and infected by virus (CTRL infect), cells treated with NP alone (Nano-mock) and not infected (Nano) and infected (Nano infect). Cell viability was measured by Alamar Blue assay (A). Resulting virus titers from the cell supernatant were measured by TCID₅₀ assay (B). Data are presented as mean ± SEM. Three independent trials were conducted. Data were analyzed by a one-way ANOVA with a Dunnett’s test. (p < 0.05). Different letters show significant differences between groups.