Table 1.
The model includes variables assessing cognitive function (ADAS and MMSE), as well as laboratory, clinical, and background variables.
| Name | Category | Type | Temporal | Statistics | Missing% |
|---|---|---|---|---|---|
| Commands | ADAS | Ordinal | Yes | 0.58 (0.84) | 0.1 |
| Comprehension | 0.40 (0.72) | 0.1 | |||
| Construction | 0.94 (0.90) | 0.1 | |||
| Delayed Word Recall | 7.94 (2.51) | 0.4 | |||
| Ideational | 0.54 (0.88) | 0.1 | |||
| Instructions | 0.78 (1.18) | 0.1 | |||
| Naming | 0.67 (0.88) | 0.1 | |||
| Orientation | 2.48 (2.02) | 0.1 | |||
| Spoken Language | 0.30 (0.69) | 0.1 | |||
| Word Finding | 0.66 (0.90) | 0.1 | |||
| Word Recall | 6.04 (1.78) | 0.1 | |||
| Word Recognition | 6.35 (3.30) | 0.1 | |||
| Attention and Calculation | MMSE | Ordinal | Yes | 2.88 (1.69) | 16.8 |
| Language | 7.90 (0.92) | 16.8 | |||
| Orientation | 6.56 (1.92) | 16.8 | |||
| Recall | 0.82 (0.88) | 16.8 | |||
| Registration | 2.90 (0.34) | 16.8 | |||
| Alanine aminotransferase | Laboratory | Continuous | Yes | 0.32 (0.14) μkat/l | 18.2 |
| Alkaline phosphatase | 1.29 (0.46) μkat/l | 18.2 | |||
| Aspartate aminotransferase | 0.37 (0.10) μkat/l | 18.2 | |||
| Cholesterol | 5.5 (1.0) mmol/l | 17.9 | |||
| Creatine kinase | 0.99 (0.62) mg/dl | 0.7 | |||
| Creatinine | 0.95 (0.22) mg/dl | 17.9 | |||
| Gamma glutamyl transferase | 2.3 (1.8) iu/dl | 32.0 | |||
| Hematocrit | 0.42 (0.04) counts | 14.7 | |||
| Hemoglobin | 14.0 (1.2) g/dl | 0.8 | |||
| Hemoglobin a1c | 5.81 (0.73)% | 48.4 | |||
| Indirect bilirubin | 0.51 (0.24) mg/dl | 48.4 | |||
| Potassium | 4.34 (0.35) mmol/l | 18.0 | |||
| Sodium | 1.41 (0.02) mmol/cl | 31.8 | |||
| Triglycerides | 1.53 (0.83) g/l | 18.1 | |||
| Blood pressure (diastolic) | Clinical | Continuous | Yes | 75.9 (8.3) mmHg | 1.8 |
| Blood pressure (systolic) | Continuous | 135 (15) mmHg | 1.8 | ||
| Heart rate | Continuous | 67.3 (8.2) bpm | 1.8 | ||
| Weight | Continuous | 71 (15) kg | 3.0 | ||
| Dropout | Binary | none | 0.1 | ||
| Age at baseline | Background | Continuous | No | 73.4 (8.4) years | 0.9 |
| Geographic region | Categorical | 67% North America | 0 | ||
| Initial diagnosis (AD or MCI) | Binary | 69% AD/31% MCI | 0 | ||
| Past cardiovascular event | Binary | 37% Y/63% N | 0 | ||
| ApoE ε4 allele count | Ordinal | 36% 0/48% 1/16% 2 | 72.4 | ||
| Race | Categorical | 93% White | 0.2 | ||
| Sex | Binary | 54% F/46% M | 0 | ||
| Height | Continuous | 165 (10) cm | 1.9 |
The statistics column gives the mean and standard deviation of the data (combining training, validation, and test data) at baseline, along with any units. For geographic region and race, the dominant category frequency is given. The missing percentage column gives the percentage of missing data for each variable at baseline.