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. 2019 Sep 20;9:13613. doi: 10.1038/s41598-019-49894-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Labeling incorporation as function of time. (A) Percentage of labeling incorporation on all detectable 219 peptides after 1 day vs 2 days of growth in labeling media (left) or after 1 day vs 3 days of labeling (right) (correlation p-value 10e-26 and 10e-12, respectively). (B) Labeling incorporation on all detectable peptides represented as box plot. (C) Labeling incorporation of the peptide of histone H3 KSTGGKAPR (aa 9–17) in all its modified forms. Cells were labeled after being synchronized and (D) not synchronized. (E) Labeling incorporation of the histone H3 residues hosting the most abundant trimethyl and acetyl marks. The comparison considers only peptides modified with a single PTM; e.g. does not include hybrid modified peptides such as H3K9me3K14ac. (F) Labeling incorporation of the histone H4 peptide GKGGKGLGKGGAKR (aa 4–17) modified with a single acetylated residue. Significance represented between H4K5ac and the other marks. All significance estimations are based on a two-tail heteroscedastic t-test (significant when p-value < 0.05).