Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 20;9:13638. doi: 10.1038/s41598-019-50093-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Altered landscape of network hubs in pediatric bipolar disorder (PBD) with psychosis. Differences in network hub regions in HC (top row) and PBD (bottom row) as measured by the normalised nodal efficiency for all 90 AAL brain regions. This shows a clear reorganisation in hub regions in PBD where e.g. the orbitofrontal cortex is no longer a hub region. (A) For the patient group, the figure shows the nodal efficiency sorted according to the mean in descending order. For each node, the E_nodal is normalised by the mean of all nodes’ E_nodal, and a node is identified as a hub region if its normalised E_nodal is larger than the sum of the mean plus the SD of all network nodes’ E_nodal. (B) Hub regions, represented as spheres positioned according to the centroid stereotaxic coordinates of the correspondent anatomical region, with node size proportional to their E_nodal, are mapped onto a 3D reconstructed brain surface. (C) The ranking of nodal efficiency, and (D) the identified hub regions for healthy participants. For each group, the existing hub nodes are represented in purple and non-hub nodes (hubs exclusive to the other group) in yellow.