Table 2.
Univariate and multivariate analyses of overall survival of hepatoblastoma
| Clinicopathological features | Univariate analyses | P value | Multivariate analyses | P value | ||
|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |||
| Age (years) | ||||||
| <Median | 1.027 | 0.436–2.420 | 0.951 | |||
| >Median | ||||||
| Gender | ||||||
| Male | 0.882 | 0.365–2.130 | 0.781 | |||
| Female | ||||||
| Tumor size | ||||||
| ≤10 cm | 1.674 | 0.693–4.044 | 0.252 | |||
| >10 cm | ||||||
| AFP | ||||||
| ≤100 ng/ml | 0.972 | 0.225–4.192 | 0.969 | |||
| >100 ng/ml | ||||||
| Histologic type | ||||||
| Epitheliated type | 0.868 | 0.317–2.378 | 0.783 | |||
| Mixed | ||||||
| Vascular invasion | ||||||
| Absent | 2.863 | 1.136–7.217 | 0.026 | 1.000 | ||
| Present | 3.914 | 1.390–11.022 | 0.010 | |||
| Distant metastasis | ||||||
| Absent | 7.841 | 3.133–19.623 | 0.000 | 1.000 | ||
| Present | 6.923 | 2.135–18.546 | 0.001 | |||
| Recurrence | ||||||
| Absent | 7.171 | 2.989–17.204 | 0.000 | 1.000 | ||
| Present | 4.158 | 1.481–11.676 | 0.007 | |||
| SIOPEL + GPOH | ||||||
| Standard-risk | 7.143 | 2.396–21.292 | 0.000 | 1.000 | ||
| High-risk | 0.820 | 0.158–4.250 | 0.814 | |||
| DPEP1 expression | ||||||
| Low | 3.565 | 1.197–10.611 | 0.022 | 1.000 | ||
| High | 6.162 | 1.952–19.727 | 0.002 | |||
Bold values indicates statistical significance, P < 0.05