Fig. 3.

cOA₄ configurations in the binding pockets. a Detailed view of the cOA₄ binding site in conf1 including its interactions with key side chains. This configuration is observed in two of the binding pockets of the hexamer (indicated with an asterisk). b The third pocket in conf1 exhibits a different configuration of cOA₄ (indicated with a black circle). c Detailed view of cOA₄ binding site in conf2 including key side chain. This configuration is visualized in two of the binding pockets of the hexamer (indicated with a black square). d The conformation of cOA₄ is also different in the third binding pocket in conf2 (indicated with a black triangle). The 2mFo-DFc electron density maps in panels A-D are displayed at 1.1 σ contour. Views of the omit maps of a–d panels are provided in Supplementary Fig. 7B