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. 2019 Sep 20;9:13648. doi: 10.1038/s41598-019-50044-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma cfDNA, IL-6 concentrations and blood leukocyte transcriptomics in healthy subjects and blunt trauma patients at ≤12 and 24 hours after injury. Panel A. Cell-free mtDNA copy number at ≤12 and 24 hours. Values represent medians, quartiles (box plots) and 95%iles (whiskers). On the left side are healthy controls and the total cohort of trauma patients in whom values were obtained. The right side contains the trauma cohort broken into subjects who died during hospitalization, rapidly recovered (RAP) or developed chronic critical illness (CCI). *p < 0.05, **p < 0.01. Panel B. Cell-free ncDNA concentrations at 12 and 24 hours. Panel C. Plasma IL-6 concentrations. Median, quartiles for patients who suffered an early death have not been included on the figure because it would expand the y-axis and compress the appearance of the other groups. In the early death patients, the median IL-6 concentration was 1501 pgs/ml (812, 4349) at ≤12 hours and 372 pgs/ml (238, 3822) at 24 hours. Panel D. s63 leukocyte transcriptomics. The expression of 63 genes was reduced to a single metric as described in the Materials and Methods, and previously published⁴³.