Table 3.

Correlations Among Biomarkers And Clinical Determinants at 24 Hours^a.

	ncDNA	mtDNA	WBC	Age	ISS	APACHE II	Initial Lactate	Maximum Lactateb	IL-6	S63 DFR
ncDNA	1	0.646	0.149	−0.051	0.203	0.030	0.166	0.130	0.108	0.219
p-value		<0.0001	0.3539	0.6102	0.0397	0.7642	0.093	0.1891	0.2835	0.0313
N	104	104	41	104	103	104	104	104	100	97
mtDNA		1	0.287	−0.089	0.084	0.040	−0.014	−0.026	0.092	0.214
p-value			0.0691	0.37	0.399	0.6889	0.8873	0.7956	0.3611	0.0356
N		104	41	104	103	104	104	104	100	97
WBC			1	−0.113	−0.008	0.082	−0.057	0.108	−0.056	0.044
p-value				0.4803	0.9605	0.6097	0.7226	0.5016	0.7326	0.8061
N			41	41	40	41	41	41	39	34
Age				1	−0.178	0.123	−0.093	−0.007	−0.088	0.067
p-value					0.0721	0.2142	0.3456	0.9402	0.3812	0.5139
N				104	103	104	104	104	100	97
ISS					1	0.420	0.353	0.339	0.347	0.371
p-value						<0.0001	0.0003	0.0005	0.0004	0.0002
N					103	103	103	103	99	97
APACHE II						1	0.280	0.379	0.338	0.440
p-value							0.0039	<0.0001	0.0006	<0.0001
N						104	104	104	100	97
Initial Lactate							1	0.814	0.208	0.327
p-value								<0.0001	0.0376	0.0011
N							104	104	100	97
Maximum Lactate								1	0.253	0.420
p-value									0.0111	<0.0001
N								104	100	97
IL-6									1	0.509
p-value										<0.0001
N									100	93
S63 DFR										1
p-value
N										97

Abbreviations: ncDNA = nuclear DNA; mtDNA = mitochondrial DNA; WBC = white blood cell; ISS = injury severity score; APACHE II = acute physiology and chronic health evaluation II; DFR = distance from reference

^aSpearman correlation coefficients (rho) were used to determine the relationships between variables. Corresponding p-values along with the number of patients upon which these correlations were derived are also listed.

^bMaximum lactate was the greatest lactate (mmol/L) within 24 hours of injury.