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. 2019 Sep 20;10:4317. doi: 10.1038/s41467-019-11777-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — AAV9 mediated overexpression of circFndc3b enhances neovascularization and reduces fibrosis after MI in mice: a Representative images of capillary density and arterioles measured in border zone of LV infarct at 8 weeks post-MI in AAV9 control or AAV9 circFndc3b or saline treated hearts. Capillaries were stained with CD31 + (red) and arterioles stained with α-SMA (green) and nuclei were counterstained with DAPI (blue). (Scale bar 100 μm); b, c Quantification of border zone capillary number and arterioles across treatments presented as the number of CD31 + positive capillaries, α-SMA + arterioles and DAPI-stained nuclei per low power field (LPF). n = 5 mice/each group. ***p < 0.001 vs AAV9 control or saline treated hearts (one-way ANOVA); (d Representative images of Masson’s trichrome stained heart sections in the saline or AAV9 control or AAV9 circFndc3b treated hearts at 8 weeks post-MI; e Quantitative analysis of infarct size at 8 weeks post-MI in saline or AAV9 control or AAV9 circFndc3b treated hearts; n = 5 mice/each group. ***p < 0.001 vs AAV9 control or saline treated hearts (one-way ANOVA)

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