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. 2019 Sep 20;9:13659. doi: 10.1038/s41598-019-49876-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The neurogenic effect of FBS is NURR1-dependent. (A) To test whether FBS induces general neurogenesis, the expression of the neuronal-specific marker MAP2 in Nurr1-overexpressing rat NPCs on differentiation day 7 was determined. More TH+ cells were found in FBS-treated cultures, although there was also a significant increase in the number of MAP2+ cells. (B) FBS has a neurogenic effect only in the presence of NURR1. The number of MAP2+ cells did not increase in the absence of Nurr1 overexpression. FBS induced an increase in the number of GFAP+ cells in both Nurr1 retrovirus-transduced and nontransduced cultures. An anti-GFAP antibody was used as an astrocyte-specific marker. **p < 0.01. Scale bar, 20 μm. The error bars are the S.E. from two independent experiments.