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. 2019 Sep 20;10(10):700. doi: 10.1038/s41419-019-1938-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a BMDMs were treated with TNC-TNF for the indicated time points and expression levels of proteins of the NF-κB and MAPK signaling pathway were analysed by western blotting. Blots are representative of three independent repeats. b Upset plot representing the detected changes in expression between untreated and TNC-TNF treated for each of the genotypes, including up- and downregulated genes. c Gene set analysis of Tian TNF signalling via NF-κB or not via NF-κB (number of genes in the gene set are given in parentheses). The distributions of differential expression t-statistics (computed by voom) are shown for the genes within the gene set and not within the gene set for each genotype. d Comparison of differentially regulated genes in WT, xiap^−/− and xiap^−/−tnfr1^−/− macrophages after TNC-TNF treatment. Black dots represent genes that are differential at FDR < 0.05 in all three genotypes, and grey dots represent genes that are differential at FDR < 0.05 in two genotypes. e Representative western blot showing TNC-TNF treatment leads to upregulation of NLRP3, caspase-11 and pro-caspase-1, but only in xiap^−/− macrophages is caspase-1 cleavage detected. Blots are representative of three independent experiments.