Fig. 1.

Distribution of somatic aberrations in genes found significantly altered in previous GBM studies. Aberration types are encoded by different colors. Letters are used when the aberration is not shared in a pair or trio. C, private in a BTIC; D, private in a tumor and xenograft in a trio; F, private in a BTIC and xenograft in a trio; P, private in a tumor and BTIC in a trio; T, private in a tumor; X, private in a xenograft. MGMT and EGFR vIII status tiles are split when a tumor (Upper) and BTIC (Lower) differ. Loss of tumor suppresser and gain of oncogene are well-conserved in pairs and trios. The private aberrations often have low functional impact, such as shallow copy changes or a variant of unknown significance, or passenger mutations in hypermutated samples. (A) Aberrations in paired tumor and BTIC samples. (B) Aberrations in trios of tumor–BTIC–xenograft samples.