Fig. 2.

Small RNA responses in ZIKV and ZIKV∆SF1-infected Ae. aegypti. Small RNAs were sequenced at 14 d postexposure from 3 individual pools of 5 to 6 fully-disseminated Ae. aegypti mosquitoes infected with ZIKV or ZIKV∆SF1 via either a blood meal (A) or intrathoracic injections (B). Shown are size distributions of small RNAs that mapped to the ZIKV genome. Small RNA reads were normalized as percentage of reads from the total number of reads in the library and additionally normalized to the ZIKV titer in the pool of sequenced mosquitoes.