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. Author manuscript; available in PMC: 2019 Sep 21.
Published in final edited form as: Hum Genet. 2018 Oct 13;137(10):847–862. doi: 10.1007/s00439-018-1943-7

Fig. 3.

Fig. 3

Manhattan plot for the association of genome-wide SNPs with primary open-angle glaucoma in GIGA BioMe meta-analysis. Manhattan plot of the GWAS meta-analysis of GIGA and BioMe (N=1113cases/N = 1826 controls). The figure shows −log10-transformed P values for all SNPs. The upper dotted horizontal line represents the genome-wide significance threshold of P < 5.0 × 10−8; the lower dotted line indicates a P value of 1 × 10−6. Green dots represents variants in that are in linkage disequilibrium (r2 > 0.6 1000 Genomes African ancestry) with the top SNP rs141186647.