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. 2019 May 24;22(9):574–584. doi: 10.1093/ijnp/pyz023

Figure 3.

Figure 3.

Tropisetron restored control over compulsive cocaine seeking. (A) Tropisetron (1.0 mg/kg) did not alter the seeking lever-press behavior, regardless of whether pressing could trigger a footshock. (B) Tropisetron (1 mg/kg) did not affect cocaine infusion or the latency to press the seeking levers at the second cycle of footshock testing. (C) Tropisetron (3.0 mg/kg) attenuated seeking responses when seeking lever pressing could potentially deliver footshock (*P < .05 from the 55th minute compared with the saline-pretreated group when footshock was available, Bonferroni’s post hoc test; right). (D) Tropisetron (3.0 mg/kg) reduced cocaine intake and extended the latency to seek lever press at the second cycle of footshock testing. *P < .05 compared with saline-pretreated group using a Bonferroni’s post hoc. All data are mean values ± SEM. (E) Examples of seeking lever presses from 1 rat during footshock session (2 hours) with vehicle without tropisetron (3.0 mg/kg, i.p.) treatment. Sticks and arrows represent seeking lever presses and footshock, respectively.