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. 2019 Jul 1;22(9):560–573. doi: 10.1093/ijnp/pyz037

Table 5.

Most Frequent Antipsychotic Combination Pairs

2000 % 2015 %
1 Haloperidol + Olanzapine 3.8 Quetiapine + Risperidone 10.9
2 Haloperidol + Clozapine 3.7 Quetiapine + Aripiprazole 9.8
3 Haloperidol + Risperidone 2.6 Olanzapine + Aripiprazole 6.5
4 Clozapine + Amisulpride 2.2 Olanzapine + Risperidone 5
5 Benperidol + Clozapine 2.2 Clozapine + Aripiprazole 5
6 Clozapine + Olanzapine 1.7 Haloperidol + Quetiapine 4.5
7 Haloperidol + Quetiapine 1.3 Olanzapine + Quetiapine 4.5
8 Haloperidol + Perazine 1.3 Clozapine + Amisulpride 4.3
9 Clozapine + Risperidone 1.1 Haloperidol + Olanzapine 3.5
10 Flupenthixol + Olanzapine 1.1 Haloperidol + Clozapine 3.5

Table 5 shows the most frequent antipsychotic combination pairs in 2000 compared with 2015 in percent of patients. Combinations of more than 2 antipsychotics were counted accordingly for all possible combinations of 2 drugs. In grey shade, the combination pairs which were present in 2000 and 2015 are highlighted.